PLASMA CONCENTRATIONS OF TRICYCLIC ANTIDEPRESSIVE DRUGS

[Cardiotoxicity of tricyclic antidepressive agents. (Phenothiazines and imipramines)].

[Mechanisms of action of antidepressive drugs: new approaches].

En France, on compte environ 5,5 millions de Français souffrant d’épisodes dépressifs majeurs, soit 8 % de la population française. L’objectif pharmacologique pour l’ensemble des antidépresseurs proposés à ce jour aux cliniciens était d’augmenter la concentration cérébrale en monoamines. Pour ce faire, trois mécanismes principaux sont recherchés : un mécanisme d’inhibition enzymatique de la dég...

Relationship between clinical features of tricyclic antidepressant poisoning and plasma concentrations in children.

Clinical features and drug plasma concentrations were studied in 13 children admitted to hospital with tricyclic antidepressant poisoning. Patients with plasma concentrations below 500 microgram/l had anticholinergic signs and increased reflexes but did not have convulsions or cardiac arrhythmias. Four patients with plasma concentrations above 1000 microgram/l suffered convulsions, cardiac arrh...

Quantitative liquid-chromatographic technique for the simultaneous assay of tricyclic antidepressant drugs in plasma or serum.

A quantitative "high-pressure" liquid-chromatographic assay for tricyclic antidepressant drugs in plasma or serum is described in which amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyldoxepin are separated with a 10-micrometer particle size silica column and a methanol/NH4OH/NH4NO3 solvent system. The drugs and two internal standards are extracted with hexane/isoamy...

Tricyclic Antidepressants: Old Drugs-New Applications

With great interest I have read an excellent article " Evaluation of the efficacy of intrathecal injection of amitripty-line and doxepin in spinal anesthesia in comparison with bupivacaine in rats " , published in your respected journal. The authors present and elaborate a very interesting subject of the application of tricyclic antidepressants as a local anesthetic. I totally agree with the au...